Health Nucleus world-class physicians and genomic scientists

Uniquely skilled. Relentlessly dedicated. Meet the people behind the science.

No matter how advanced the science and technology, it’s the people applying it that have the power to make the biggest impact. Our physicians combine their passion for medicine with a deep and sincere desire to treat the whole person and not just their symptoms. They are particularly skilled in interpreting large data sets to glean critical health information that can be acted upon to preempt disease and drive optimal health through a unique combination of traditional, integrative and functional medicine.

Health Nucleus Physicians Group

David Karow, MD, PhD, As Chief of Performance Medicine and Medical Imaging for Health Nucleus

David Karow, MD, PhD

As President and Chief of Radiology for Health Nucleus, I am on a mission to optimize the longevity and personal performance of our patients. My goal for Health Nucleus is to change sick” care to health care, as the leader of whole genome genetic interpretation, whole body imaging, and advanced blood work.

EDUCATION

B.S, University of Michigan, Concentration: Cellular and Molecular Biology (1994)
MD, PH.D in Cellular and Molecular Biology  University of Michigan (2005)

Internship in Internal Medicine, University of California, Irvine (2005 - 2006)

Residency in Diagnostic Radiology, University of California, San Diego (July 2006 – June 2011)

Fellowship in Abdominal Imaging and Cross-sectional Interventional, University of California, Los Angeles (2011 – 2012)

ACCREDITATIONS

Medical Board of California, Physician and Surgeon (2006 – present)
Board Certified, American Board of Radiology, Diagnostic (2011 – present)
California X-Ray Supervisor & Operator Permit,  (2011 – present)

PUBLICATIONS

Precision Medicine Integrating Whole-Genome Sequencing, Comprehensive Metabolomics, and Advanced Imaging
“Genome sequencing has established clinical utility for rare disease diagnosis. While increasing numbers of individuals have undergone elective genome sequencing, a comprehensive study surveying genome-wide disease-associated genes in adults with deep phenotyping has not been reported. Here we report the results of a 3-y precision …”

An Unsupervised Learning Approach to Identify Novel Signatures of Health and Disease From Multimodal Data
“…multimodal data integration, from the identification of novel biomarker signatures to a data-driven stratification of individuals into disease subtypes and stages-an essential step towards personalized, preventative health risk assessment.”

Utility of Restriction Spectrum Imaging Among Men Undergoing First-Time Biopsy for Suspected Prostate Cancer
“Evaluate restriction spectrum imaging (RSI) in men undergoing MRI-ultrasound fusion biopsy for suspected prostate cancer (PCa) and to compare the performance of RSI.. “

Relationship Between Kurtosis and Bi-Exponential Characterization of High B-Value Diffusion-Weighted Imaging: Application to Prostate Cancer
“High b-value diffusion-weighted imaging has application in the detection of cancerous tissue across multiple body sites. Diffusional kurtosis and bi-exponential modeling are two popular model-based techniques…”

Precision Medicine Screening Using Whole-Genome Sequencing and Advanced Imaging to Identify Disease Risk in Adult
“Using genomics in combination with advanced imaging and other clinical testing to proactively screen for age-related chronic disease...”

Polygenic Hazard Score to Guide Screening for Aggressive Prostate Cancer: Development and Validation in Large Scale Cohorts
“Predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen…”

Genetic Assessment of Age-Associated Alzheimer Disease Risk: Development and Validation of a Polygenic Hazard Score
“Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk…”

Restriction Spectrum Imaging: An Evolving Imaging Biomarker in Prostate MRI
“Restriction spectrum imaging (RSI) is a novel diffusion-weighted MRI technique that uses the mathematically distinct behavior of water diffusion…”

Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index With Gleason Grade in Prostate Cancer
“We evaluated the reliability of RSI-MRI to predict variance with GG at the voxel-level within clinically demarcated prostate cancer”

Restriction Spectrum Imaging Improves MRI-based Prostate Cancer Detection
“To compare the diagnostic performance of restriction spectrum imaging (RSI), with that of conventional multi-parametric (MP) magnetic resonance imaging (MRI) for prostate cancer (PCa) detection”

In Vivo Prostate Cancer Detection and Grading Using Restriction Spectrum imaging-MRI
“ RSI-MRI significantly improves upon current noninvasive PCa imaging and may potentially…”

Parenchymal Volumetric Assessment as a Predictive Tool to Determine Renal Function Benefit of Nephron-Sparing Surgery Compared With Radical Nephrectomy
“Volumetric-based assessment provides information to predict postoperative eGFR. A tool based on this equation may assist surgical counseling regarding…”

Prostate Diffusion Imaging With Distortion Correction
“Diffusion imaging in the prostate is susceptible to distortion from B0 inhomogeneity. Distortion correction in prostate imaging is not routinely performed, resulting in…”

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease
“Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated…”

MRI-Derived Restriction Spectrum Imaging Cellularity Index Is Associated With High Grade Prostate Cancer on Radical Prostatectomy Specimens
“The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance…”

Novel Technique for Characterizing Prostate Cancer Utilizing MRI Restriction Spectrum Imaging: Proof of Principle and Initial Clinical Experience With Extraprostatic Extension
“Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we developed a novel, enhanced MRI diffusion technique…”

Diffusion-weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging“
The scope of DWI has since broadened to include oncologic imaging of the prostate gland, breast, and liver. Despite its growing success and application, misconceptions about the underlying physical basis of the DWI signal exist…”

Relative Capability of MR Imaging and FDG PET to Depict Changes Associated With Prodromal and Early Alzheimer Disease

Combining MR Imaging, Positron-Emission Tomography, and CSF Biomarkers in the Diagnosis and Prognosis of Alzheimer Disease
“To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers…”

Structural MRI Biomarkers for Preclinical and Mild Alzheimer's Disease
“Noninvasive MRI biomarkers for Alzheimer's disease (AD) may enable earlier clinical diagnosis and the monitoring of therapeutic effectiveness. To assess potential neuroimaging biomarkers, the Alzheimer's Disease Neuroimaging Initiative is following normal controls (NC) and individuals with mild cognitive impairment…”

Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases
“Homeostatic sensory systems detect small deviations in temperature, water balance, pH, and energy needs to regulate adaptive behavior and physiology. In C. elegans, a homeostatic preference for intermediate oxygen (O2) levels requires cGMP signaling through soluble guanylate cyclases (sGCs)…”

Alzheimer Disease: Quantitative Structural Neuroimaging for Detection and Prediction of Clinical and Structural Changes in Mild Cognitive Impairment
“Semiautomated, individually specific quantitative MR imaging methods can be used to identify a pattern of regional atrophy in MCI…”

Multi-modal Imaging Predicts Memory Performance in Normal Aging and Cognitive Decline
“This study (n=161) related morphometric MR imaging, FDG-PET and APOE genotype to memory scores in normal controls (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD). Stepwise regression analyses focused on morphometric and metabolic characteristics of the episodic memory network…”

A Distributed Chemosensory Circuit for Oxygen Preference in C. Elegans
“The nematode Caenorhabditis elegans has complex, naturally variable behavioral responses to environmental oxygen, food, and other animals. C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently…”


Nitric Oxide Binding to Prokaryotic Homologs of the Soluble Guanylate Cyclase beta1 H-NOX Domain
“The heme cofactor in soluble guanylate cyclase (sGC) is a selective receptor for NO, an important signaling molecule in eukaryotes. The sGC heme domain has been localized to the N-terminal 194 amino acids of the beta1 subunit of sGC and is a member of a family of conserved hemoproteins, called the H-NOX family…”

Characterization of Functional Heme Domains From Soluble Guanylate Cyclase
“Soluble guanylate cyclase (sGC) is a heterodimeric, nitric oxide (NO)-sensing hemoprotein composed of two subunits, alpha1 and beta1. NO binds to the heme cofactor in the beta1 subunit…”

Crystal Structure of an Oxygen-Binding Heme Domain Related to Soluble Guanylate Cyclases
“Soluble guanylate cyclase (sGC) is a heterodimeric, nitric oxide (NO)-sensing hemoprotein composed of two subunits, alpha1 and beta1. NO binds to the heme cofactor in the beta1 subunit, forming a five-coordinate NO complex that activates the enzyme several hundred-fold…This paper has identified and characterized the minimum functional ligand-binding heme domain derived from sGC…”

Spectroscopic Characterization of the Soluble Guanylate Cyclase-Like Heme Domains From Vibrio Cholerae and Thermoanaerobacter Tengcongensis
“Soluble guanylate cyclase (sGC) is a nitric oxide- (NO-) sensing hemoprotein that has been found in eukaryotes from Drosophila to humans. Prokaryotic proteins with significant homology to the heme domain of sGC have recently been identified through genomic analysis…The first is a 181 amino acid protein cloned from Vibrio cholera…The second protein is the N-terminal 188 amino acids of Tar4…”

Oxygen Sensation and Social Feeding Mediated by a C. Elegans Guanylate Cyclase Homologue
“Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen…”

RNA Polymerase II-dependent Positional Effects on mRNA 3' End Processing in the Adenovirus Major Late Transcription Unit
“Our results are consistent with recent reports demonstrating that the processing factors cleavage and polyadenylation specificity factor and cleavage stimulatory factor are associated with the RNA polymerase II holoenzyme…”


Keith Vaux, MD

Chief Medical Officer for Health Nucleus

EDUCATION

1982 - 1984 Human Sciences: Oxford University, Mansfield College, Oxford, England
1984 – 1987 B.A.: History, Philosophy and Social Studies of Science and Medicine, University of Chicago, Chicago, IL
1990 - 1994 M.D.: University of Chicago, Pritzker School of Medicine, Chicago, IL
1994 - 1995 Internship, Naval Medical Center, San Diego CA
1995 - 1997 Residency, Pediatrics Naval Medical Center, San Diego CA
1996 - 1997 Chief Residency: Pediatrics, Naval Medical Center, San Diego CA
2001 - 2004 Fellowship: Dysmorphology and Medical Genetics with additional certificate in Teratology, University of California, San Diego, CA.

ACCREDITATIONS

California Medical License, Active
American Board of Pediatrics, Active
Drug Enforcement Administration, Controlled Substance Registration Certification
Pediatric Advanced Life Support Certification
Basic Life Support Certification

PUBLICATIONS

1. Rydman, R.J., Yale, S.M., Vaux, K.K., Mullner, R.M. “Preventive Control of AIDS: A Survey of Dental Practices in a Large Urban Area.” Journal of Public Health Dentistry. Vol. 50(1), 1990.

2. Rydman, R.J., Mullner, R.M., Vaux, K.K., Kampe, L. “Using the Emergency Department Medical Record in Financial and Epidemiologic Research.” Journal of Health Information Management Research. Vol. 1(1), 1992.

3. Wheeler, D.S., Vazquez, W.D., Vaux, K.K., Poss, W.B. “Streptococcal pyomyositis: case report and review.” Pediatr Emerg Care. 14(6): 411-2, 1998.

4. Wheeler, D.S., Sperring, J.L., Vaux, K.K., Poss, W.B. “Development of a Pediatric critical care transport team: experience at a military medical center.” Mil Med. 164(3): 188-93, 1999.

5. Wheeler, D.S., Vaux, K.K., Starr, S.R., Poss, W.B. “The Pediatric Critical Care Experience at Naval Hospital Guam: Suggestions for critical care training during residency.” Mil Med. 165(6):441-4, 2000.

6. Wheeler, D.S., Vaux, K.K., Tam, D.A. “Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy.” Pediatr Neurol. 22(3): 220-1, 2000.

7. Vaux, K.K., Wojtczak, H., Benirschke, K., Jones, K.L. “Vocal Cord Abnormalities in Williams Syndrome: A Further Manifestation of Elastin Deficiency.” Am J Med Genet. 119A(3): 302-304, 2003.

8. Vaux KK, Khaole N, Jones KL. “Cyclophophamide, Methotrexate and Cytarabin Embryopathy: Is Apoptosis the Common Pathway?” Clinical and Molecular Teratology. 67(6) 403-8, 2003.

9. Wheeler DS, Vaux KK, Ponaman ML, Poss BW. “The safe and effective use of propofol sedation in children undergoing diagnostic and therapeutic procedures: experience in a pediatric ICU and a review of the literature. “Pediatr Emerg Care. 19(6):385-92, 2003.

10. Emery SC, Vaux KK, Pretorius D, Masliah E, Benirschke K. Acardiac Twin with Externalized Intestine Adherent to Placenta: Unusual Manifestation of Omphalocele. Pediatric Dev Pathol. 7(1) 2004.

11. Vaux KK, Benirschke K, Jones, MC, Jones, KL. “Megalourethra: A report of three cases associated with maternal diabetes and a review of the literature. Is sonic hedgehog the common pathway?” Am J Med Genet A. 2005 Jan 30;132A(3):314-7.

12. Vaux KK, Hudgins L, Roeder E, Curry C, Jones MC, Jones KL. “The Neonatal Phenotype of Kabuki Syndrome.” Am J Med Genet A. 2005 Jan 30;132A(3):244-7.

13. Vaux KK, Jones MC, Jones KL, Schelley S, Hudgins L. “Developmental Outcome in Kabuki Syndrome” Am J Med Genet A. 2005 Jan 30;132A(3):263-4.

14. N. Revencu, L.M. Boon, J.B. Mulliken, O. Enjolras, M.R. Cordisco, P.E. Burrows, P.H. Clapuyt, F. Hammer, J. Dubois, E. Baselga, F.Brancati, B. Dallapiccola, R. Carder, G. Fischer, I. Frieden, J Harper, P. Gritters, J Johnson Patel, C. Labrèze, L. Martorell, H. J. Paltiel, A. Pohl, J. Prendiville, I. Quere, D.H. Siegel, E.M. Valente, K.K. Vaux, L. Weibel, J.M. Ceballos Quintal, D. Chitayat and M. Vikkula. “Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies and specific neural tumors associated with RASA1 mutations.” Human Mutation. 2008 Apr 29.

15. Jones KL, Webster WS, Vaux KK, Benirschke K. “Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting.” Birth Defects Res A Clin Mol Teratol. 2008 Aug;82(8):597-600.

16. Dimmock D, Trapane P, Feigenbaum A, Keegan CE, Cederbaum S, Gibson J, Gambello MJ, Vaux K, Ward P, Rice GM, Wolff JA, O'Brien WE, Fang P. “Novel human pathological mutations. Gene symbol: ASS1. Disease: Citrullinaemia.” Hum Genet. 2009 Aug;126(2):341.

17. Baughn MR, Vaux K, Masliah E. Placenta Accreta in a Separate Uterine Horn. Pediatr Dev Pathol. 2009 Jul 28:1.

18. Hackett LK, Tarsa M, Wolfson TJ, Kaplan G, Vaux KK, Pretorius DH. Use of multiplanar 3-dimensional ultrasonography for prenatal sex identification. J Ultrasound Med. 2010 Feb;29(2):195-202.

19. Dimmock DP, Trapane P, Feigenbaum A, Keegan CE, Cederbaum S, Gibson J, Gambello MJ, Vaux K, Ward P, O'Brien WE, Fang P. The role of molecular testing and enzyme analysis in the management of hypomorphic citrullinemia. Am J Med Genet A. 2010 Apr;152A(4):1061.

20. Eichenfield LF, Krakowski AC, Piggott C, Del Rosso J, Baldwin H, Friedlander SF, Levy M, Lucky A, Mancini AJ, Orlow SJ, Yan AC, Vaux KK, Webster G, Zaenglein AL, Thiboutot DM. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013 May;131 Suppl 3:S163-86.

21. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013 Aug 1;154(3):505-17.

22. Rosti RO, Sadek AA, Vaux KK, Gleeson JG. The Genetic Landscape of Autism Spectrum Disorders. Developmental Medicine and Child Neurology. 2013 Oct 1. 56(1):12-8

23. Gaia Novarino, Ali G. Fenstermaker, Maha S. Zaki, Matan Hofree, Jennifer L. Silhavy, Andrew D. Heiberg, Mostafa Abdellateef, Basak Rosti, Eric Scott, Lobna Mansour, Amira Masri, Hulya Kayserili, Jumana Y. Al-Aama, Ghada M.H. Abdel-Salam, Ariana Karminejad, Majdi Kara, Bulent Kara, Bita Bozorgmehri, Tawfeg Ben-Omran, Faezeh Mojahedi, Iman Gamal El Din Mahmoud, Naima Bouslam, Ahmed Bouhouche, Ali Benomar, Sylvain Hanein, Laure Raymond, Sylvie Forlani, Massimo Mascaro, Laila Selim, Nabil Shehata, Nasir Al-Allawi, P.S. Bindu, Matloob Azam, Murat Gunel, Ahmet Caglayan, Kaya Bilguvar, Asli Tolun, Mahmoud Y. Issa, Jana Schroth, Emily G. Spencer, Rasim O. Rosti, Naiara Akizu, Keith K. Vaux, Anide Johansen, Alice A. Koh, Hisham Megahed, Alexandra Durr, Alexis Brice, Giovanni Stevanin, Stacy Gabriel, Trey Ideker, Joseph G. Gleeson. Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders. Science. 2014 Jan 31;343(6170):506-11.

24. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagıroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nature Genetics. 2015 May;47(5):528-34.

25. Chambers, CD; Zellner, JA, Feldman, H; Akshoomoff, N; Xu, R; Coles, CD; Kable, JA; Manning, M; Adam, M; Vaux, K; Developing A Valid Prevalence Estimate For Fetal Alcohol Spectrum Disorders In A Large, Diverse Urban US Community. Alcoholism: Clinical & Experimental Research. 2015 June: 260A

26. Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nature Genetics. 2015 Jul;47(7):809-13.

27. Roosing S, Hofree M, Kim S, Scott E, Copeland B, Romani M, Silhavy JL, Rosti RO, Schroth J, Mazza T, Miccinilli E, Zaki MS, Swoboda KJ, Milisa-Drautz J, Dobyns WB, Mikati M, İncecik F, Azam M, Borgatti R, Romaniello R, Boustany RM, Clericuzio CL, D'Arrigo S, Strømme P, Boltshauser E, Stanzial F, Mirabelli-Badenier M, Moroni I, Bertini E, Emma F, Steinlin M, Hildebrandt F, Johnson CA, Freilinger M, Vaux KK, Gabriel SB, Aza-Blanc P, Heynen-Genel S, Ideker T, Dynlacht BD, Lee JE, Valente EM, Kim J, Gleeson JG. Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome. Elife. 2015 May 30;4.

28. Rosti RO, Dikoglu E, Zaki MS, Abdel-Salam G, Makhseed N, Sese JC, Musaev D, Rosti B, Harbert MJ, Jones MC, Vaux KK, Gleeson JG. Extending the mutation spectrum for Galloway-Mowat syndrome to include homozygous missense mutations in the WDR73 gene. American Journal of Medical Genetics. Part A. 2016; 170A(4):992-8.

29. Ilse Meerschaut, Justine Pètre, Nicole Revencu, Damien Lederer, Milen Vilenov, Thomy de Ravel, Djalila Mekahli, Keith Vaux, Jonathan Sebat, Fadi Hamdan, Jacques Michaud, Pablo Lapunzina, Nataliya Di Donato, Louanne Hudgins, Andrea Hanson- Kahn, Bruno Dallapiccola, Antonio Novelli, Joris Andrieux, Magdalena Budisteanu and Bert Callewaert. FOXP1-related Intellectual Disability Syndrome: a Recognizable Entity. Belgian Journal of Pediatrics, 2016 18:99–99.

30. Brandler WM, Antaki D, Gujral M, Noor M, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fuentes Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM Corsello C, and Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. American J Human Genetics. 2016 Apr 7;98(4):667-79.

31. Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 Apr 20;360(6386):327-331.

32. Meerschaut I, Rochefort D, Revençu N, Pètre J, Corsello C, Rouleau Ga, Hamdan Ff, Michaud Jl, Morton J, Radley J, Ragge N, García-Miñaúr S, Lapunzina P, Bralo Mp, Mori Má, Moortgat S, Benoit V, Mary S, Bockaert N, Oostra A, Vanakker O, Velinov M, De Ravel Tj, Mekahli D, Sebat J, Vaux KK, Didonato N, Hanson-Kahn Ak, Hudgins L, Dallapiccola B, Novelli A, Tarani L, Andrieux J, Parker Mj, Neas K, Ceulemans B, Schoonjans As, Prchalova D, Havlovicova M, Hancarova M, Budisteanu M, Dheedene A, Menten B, Dion Pa, Lederer D, Callewaert B. Foxp1-Related Intellectual Disability Syndrome: A Recognisable Entity. Journal Of Medical Genetics 2017;54:613-623.

33. May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D, Kopald D, Hasken JM, Xu R, Honerkamp-Smith G, Taras H, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Vaux K, Jewett T, Elliott AJ, Kable JA, Akshoomoff N, Falk D, Arroyo JA, Hereld D, Riley EP, Charness ME, Coles CD, Warren KR, Jones KL, Hoyme HE. Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. JAMA. 2018 Feb 6;319(5):474-482.

34. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 Sep 6;103(3):431-439. Epub 2018 Aug 9. Erratum in: Am J Hum Genet. 2018 Nov 1;103(5):826.

35. Borok J, Ferris K, Vaux K, Krakowski AC. Inside "Outside" Job: Unexpected Geometric Skin Ulcerations Overlying Orthopedic Hardware After Multimodal Laser Scar Revision. Dermatol Surg. 2018 Sep;44(9):1231-1233.

36. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 Nov 1;103(5):826.

37. Chambers CD, Johnson DL, Xu R, Luo Y, Lopez-Jimenez J, Adam MP, Braddock SR, Robinson LK, Vaux K, Lyons Jones K; OTIS Collaborative Research Group. Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study. PLoS One. 2019;14(10):e0223603. 2019 Oct 18.

Other Publications:

1. Vaux KK. “A Clinical Guide to Inherited Metabolic Diseases, 2nd ed.” J Hered. 94(2):195, 2003.

2. Stellwagen LM, Hubbard E, Vaux, KK. “Look For the ‘Stuck Baby’ to Identify Congenital Torticollis” Contemporary Pediatrics. March 18, 2004.

3. Vaux KK, Chambers C. “Fetal Alcohol Syndrome” eMedicine from WebMD. Sept 2006, Updated October 17, 2015. Available at: http://emedicine.medscape.com/article/974016- overview.

Chapters:

1. Vaux KK, Chan L, Jones KL: Teratology. In Spitzer, Critical Care of the Neonate, Third Edition. April 2005.

2. Hudgins L and Vaux KK. Pectoral Girdle, Spine, Ribs, and Pelvic Girdle. In Human Malformations and Related Anomalies, 2nd edition. April 2005.

Abstracts:

1. Vaux KK, King JC, Jones KL. “Multiple Circumferential Constriction Rings with Lineal Creases Over the Tibia, Mental Retardation and Autosomal Recessive Inheritance.” DWS Workshop on Morphogenesis, San Diego, CA. Proceedings of the Greenwood Genetic Center. 20:168-169. 2001.

2. Vaux KK, Khaole N, Jones KL. “Cyclophophamide, Methotrexate and Cytarabin Embryopathy: Is Apoptosis the Common Pathway?” Platform Presentation, Western Society for Pediatric Research, Carmel CA. David W. Smith Young Investigator Award.

3. Vaux KK, Khaole N, Jones KL. “Cyclophophamide Embryopathy.” Platform Presentation, Teratology Society Meeting, Scottsdale AZ. Teratology 65(6):297, 2002. Student Award Winner.

4. Hudgins L, Vaux KK, Jones M, Jones KL, Grix A, Schelley S. “Developmental Outcome in Kabuki Syndrome.” Platform Presentation, DWS Workshop on Morphogenesis, Greenville, SC. Proceedings of the Greenwood Genetic Center, 2003.

5. Vaux KK, Hudgins L, Roeder E, Curry C, Jones MC, Jones KL. “The Neonatal Phenotype of Kabuki Syndrome” Platform presentation, DWS Workshop on Morphogenesis, Greenville SC. Proceedings of the Greenwood Genetic Center, 2003.

6. Vaux KK, Benirschke K, Bird L, Jones KL. “Left-Right Axis Defects in Infants of Women with Diabetes: Further Evidence of the Link between Maternal Diabetes and Sonic Hedgehog.” DWS Workshop on Morphogenesis, Vancouver, BC. Proceedings of the Greenwood Genetic Center, 2004.

7. Vaux, KK, Jones, KL. “Marshall Syndrome.” Platform Presentation, Western Society for Pediatric Research, Carmel, CA 2004. Journal of Investigative Medicine. 52:1. 2004.

8. Vaux KK, Jones KL, Benirschke K. “The Acardiac Fetus: Evidence in Support of a Vascular Pathogenesis for Isolated Clefting.” Platform Presentation, DWS meeting. Proceedings of the Greenwood Genetic Center, 2004.

9. Vaux KK, Chambers CH, Chamit R, Benirshke K, Vanazzi E, Jones KL. “Placental Abnormalities associated with Misoprostol Administration.” Platform Presentation, 44th Teratology Society Annual Meeting, Vancouver, BC. June 30, 2004. Student Award Winner.

10. Vaux KK, Masliah E, Crews L, Jones KL. “Abnormal Pax1 expression is a factor in vertebral and rib anomalies seen in VATER association.” Platform Presentation, DWS meeting. Proceedings of the Greenwood Genetic Center, 2005. August 18-21, 2004. Snowbird, Utah.

11. Vaux KK, Benirschke K, Mannino F, Jones KL. “Placental Anomalies in Artificial Reproductive Technology Conceived Pregnancies.” Platform Presentation, DWS meeting. Proceedings of the Greenwood Genetic Center, 2005. August 18-21, 2004. Snowbird, Utah.

12. Vaux KK, Jones KL. “Ziprasidone Embryopathy: Are the defects caused by pharmacologically induced fetal arrhythmias?” Platform Presentation, Western Society for Pediatric Research, Carmel, CA, 2005. Young Investigator Award Winner.

13. Vaux KK, Benirschke K. “Conjoined Twins: Fission or fusion, could the answer be so simple?” Platform Presentation, Judy Hall Symposium of Congenital Anomalies and Developmental Mechanisms, Carmel, CA. February 5, 2005.

14. Vaux KK, Hudgins L. “Capillary Malformation, Arterial Venous Malformation Syndrome.” Platform Presentation, DWS Workshop on Morphogenesis. September 2006.

15. Vaux KK, Bird LM., Mortimer D. “Multiple arterial aneurysms in a 6-week old infant.” David W. Smith workshop on malformations and morphogenesis. 2012.

Presentations

1. “Overview of a Pediatric Transport Service,” Pediatric Transport Medicine Conference, San Diego CA, 1996.

2. “Management of Pediatric Airway During Transport,” Pediatric Transport Medicine Conference, San Diego, CA, 1996.

3. “Conotruncal Heart Lesions, History and Future Direction,” Chief Resident Lecture, Naval Medical Center, San Diego Grand Rounds, 2007.

4. “Back to Sleep Program,” Guam Department of Public Health, Guam, USA, 1998.

5. “Asthma Care,” Guam Department of Public Health, Guam, USA, 1998.

6. “Multiple Circumferential Constriction Rings with Lineal Creases Over the Tibia, Mental Retardation and Autosomal Recessive Inheritance,” DWS Workshop on Morphogenesis, San Diego, CA, August 2001.

7. “Cyclophophamide, Methotrexate and Cytarabin Embryopathy: Is Apoptosis the Common Pathway?” Platform Presentation, Western Society for Pediatric Research, Carmel, CA, January 2002.

8. “Cyclophophamide Embryopathy,” Platform Presentation, Teratology Society Meeting, Scottsdale, AZ, Student Award Winner, February 2002.

9. “Dysmorphology and Genetics in the Community Nursery,” 36th Annual Uniformed Services Pediatric Seminar, American Academy of Pediatrics, San Diego, CA 2002.

10. “The Fetal Alcohol Syndrome,” San Diego County Public Health Nursing, Annual Meeting, San Diego, CA, 2003.

11. “CHARGE Association,” Perinatal Care Continuing Education Conference, Naval Medical Center, San Diego, CA, 2003.

12. “Developmental Outcome in Kabuki Syndrome,” Platform Presentation, DWS Workshop on Morphogenesis, Greenville, SC, August 2003.

13. “The Neonatal Phenotype of Kabuki Syndrome,” Platform presentation, DWS Workshop on Morphogenesis, Greenville, SC, August 2003.

14. “Expanded Newborn Screening Program, Disparity Among Military Dependents,” World Congress on Disabilities, Orlando, FL, September 19, 2003.

15. “Placental Abnormalities associated with Misoprostol Administration,” Platform Presentation, Teratology Society Annual Meeting, Vancouver, British Columbia, Canada, Student Award Winner, June 30, 2004.

16. “Abnormal Pax1 expression is a factor in vertebral and rib anomalies seen in VATER association,” Platform Presentation, DWS Meeting, Snowbird, Utah, August 18-21, 2004.

17. “Placental Anomalies in Artificial Reproductive Technology Conceived Pregnancies.” Platform Presentation, DWS meeting. Snowbird, Utah. August 18-21, 2004.

18. “Diabetic Embryopathy,” Pediatric Grand Rounds, Tripler Army Medical Center, HI, March 22, 2004.

19. “Genetic causes of IUGR,” Pediatric Grand Rounds, Tripler Army Medical Center, HI, March 24, 2004.

20. “PAX 1 Expression is abnormal in VATER syndrome,” Pediatric Pathology Grand Rounds, University of California, San Diego, May 19, 2004.

21. “Genetics in the Newborn Nursery,” Southern California Association of Neonatal Nurses (SCANN), Annual Meeting, UCSD, March 2005.

22. “Ziprasidone Embryopathy: Are the defects caused by pharmacologically induced fetal arrhythmias?” Platform Presentation, Western Society for Pediatric Research, Carmel, CA. Young Investigator Award Winner, January 2005.

23. “Conjoined Twins: Fission or fusion, could the answer be so simple?” Platform Presentation, Judy Hall Symposium of Congenital Anomalies and Developmental Mechanisms, Carmel, CA, February 5, 2005.

24. Left-Right Axis Defects in Infants of Women with Diabetes: Further Evidence of the Link between Maternal Diabetes and Sonic Hedgehog,” DWS Workshop on Morphogenesis, Vancouver, BC, August 2005.

25. “Genetic Conditions Incompatible with Life,” Continuing Medical Education Conference, Southern California Association of Neonatal Nurses (SCANN), San Diego Hospice and Palliative Care, May 2006.

26. “Capillary Malformation, Arterial Venous Malformation Syndrome,” Platform Presentation, DWS Workshop on Morphogenesis, September 2006.

27. “Development of the Vascular System,” Cedar Sinai Genetics Grand Rounds, Los Angeles, CA, December 2006.

28. “Recognition, Management and Etiology of Pediatric Seizures,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, October 8, 2008.

29. “The Technology Dependent Child,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, April 15, 2009.

30. “Evidence Based Medicine and Leading a Health Care Team,” UCSD Pediatric Fellowship Core Curriculum, San Diego, CA, October 10 2009.

31. “New Genetics and Personalized Medicine,” World Congress on Disabilities, Jacksonville, FL, November 19, 2009.

32. “Genetics Primer,” UCSD Pediatric Resident Core Curriculum, San Diego, CA, February 17, 2010.

33. “Common Syndromes and Genomic Sciences: How genetics will change our understanding of human disease,” Southern California Association of Neonatal Nurses (SCANN), San Diego, CA, May 10, 2010.

34. “Trisomy 13 and 18, a Review and Discussion,” RCHSD Ethics Forum, San Diego, CA, November 6, 2010.

35. “Genetic Disorders of Connective Diseases,” UCSD Pediatric Resident Core Curriculum, San Diego, CA, November 19, 2010.

36. “Recognition, Management and Etiology of Pediatric Seizures,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, San Diego, CA, 2011.

37. “The Technology Dependent Child,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, San Diego, CA, 2011.

38. “Evidence Based Medicine,” UCSD Pediatric Fellowship Core Curriculum, San Diego, CA, 2011.

39. “Metabolic Emergencies,” Childrens’ Hospital Emergency Transport Team Core Lecture Series, San Diego, CA, February 8, 2011.

40. “Metabolic Emergencies,” Children’s Hospital Emergency Transport Team Core Lecture Series, San Diego, CA, November 8, 2011.

41. “Middle East Siblings with Complex Genetic Defects,” RCHSD Patient Care Operations Council, November 8, 2011.

42. “Evidence Based Medicine,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, November 9, 2011.

43. “Seizures” and “Caring for the Medically Complex Child,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, San Diego, CA, November 9, 2011.

44. “Update on Genetic Testing and its impact on Patient Care,” Pediatric Grand Rounds at Scripps Mercy Hospital, March 15, 2012.

45. “Evidence Based Medicine,” UCSD Pediatric Fellowship Core Curriculum, San Diego, CA, 2012.

46. “The Technology Dependent Child,” Pediatrics and Hospital Medicine Fellowship Core Curriculum, San Diego, CA, 2012.

47. “Undiagnosed Neurogenetic Diseases,” UCSD Pediatric Resident Core Curriculum, San Diego, CA, February 4, 2013.

48. “Undiagnosed Neurogenetic Diseases”, Pediatric Resident Core Conference, San Diego, CA, February 4 2013.

49. “Advances in Genetics: How will they impact your practice?” 27th Annual American Academy of Pediatrics Advances in the Practice of Pediatrics, San Diego, CA, March 20, 2013.

50. “Dermatologic Manifestations of Systemic Diseases” American Academy of Pediatrics Advances in the Practice of Pediatrics” San Diego, CA February 2014.

51. “Visual Diagnosis, Genetic Diseases” American Academy of Pediatrics 28th Annual Advances in the Practice of Pediatrics. San Diego, CA February 2014.

52. “Trisomy 21” Plenary, 2014 American Academy of Pediatrics, National Conference and Exhibition, San Diego October 2014.

53. UC San Diego Department of Medicine Grand Rounds “Precision Medicine” February 18, 2015.

54. TedMed UCSD moderator for Session 1 - Human Explorations, from 6-8:30 pm on Wednesday November 18th 2016.

55. “Genetics-Next Generation Techniques” - Annenberg Center for Health Sciences at Eisenhower Medical Center, February 1, 2018.

56. Webinar UCSD - CBD and ASD


Pamila Brar, MD, As the Chief Medical Director for Health Nucleus

Pamila Brar, MD

As the Chief Medical Director for Health Nucleus, I have a deep desire to translate complex medical data into accessible and actionable information that can change our patients’ lives for the better.

EDUCATION

MD, Louisiana State University School of Medicine at New Orleans (1995)

Chief Resident, Scripps Clinic Internal Medicine Residency (1998 -1999)

President of American Academy of Private Physicians, 2015-2017

ACCREDITATIONS

American Board of Internal Medicine
American Board of Integrative and Holistic Medicine

PUBLICATIONS

Precision Medicine Screening Using Whole-Genome Sequencing and Advanced Imaging to Identify Disease Risk in Adults


Mona Ezzat Velinov, MD, ABFM, ABIHM, IFMCP, Physician at Health Nucleus

Mona Ezzat Velinov, MD, ABFM, ABIHM, IFMCP

As a physician at Health Nucleus, I believe health can flourish throughout our lifetime. From the microbiome to brain health, our daily habits connect all of our systems to one amazing network.

EDUCATION

University of Iowa, Iowa City. IA., Bachelor of Arts, Biology with Honors (1991-1998)

Rush Medical College, Chicago, IL, Doctor of Medicine (1992-1996)

University of Michigan, Ann Arbor, MI Internship and Residency, Family Practice (1996-1999)

ACCREDITATIONS

American Board of Family Practice, 2017
American Board of Integrative and Holistic Medicine 2013
Institute of Functional Medicine Certified Practitioner 2019

PUBLICATIONS

Chapter: Circadian rhythm in the Digital Age in The Handbook of Wellness Medicine
To be published August, 2020


Robyn Heister, MD Physician at Health Nucleus

Robyn Heister, MD

I joined the team of physicians at Health Nucleus in 2017 with the goal of empowering patients to draw their own blueprints for healing and to continue to mentor healthcare providers on how to use emerging innovation and technology in their practice.

EDUCATION

Emergency Medicine Resident, University of California, San Diego, CA (2002-2005)

Transitional Year Internship, Scripps Mercy Hospital, San Diego, CA (2001-2002)

Doctor of Medicine, University of California at Davis, Davis, CA (1997-2001)

Coursework in Pre-Med, University of California at Los Angeles, Los Angeles, CA (1994-1997)

Bachelor of Arts in Human Biology, Emphasis on Disability & Development, Stanford University, Palo Alto, CA (1989-1993)

PeopleSeq Consortium (NIH) Participated in the ongoing efforts of NIH-funded study to evaluate the medical, behavioral and economic impact of genomic sequencing on healthy populations (2017-2019)

CEP Leadership Series, Emeryville, CA, (2012)

Credentials and Partner Affairs Committee (CPAC) for Vituity, Emeryville, CA (2010 – 2012)

American College of Emergency Physicians

California Medical Association

ACCREDITATIONS

Medical licensure California

PUBLICATIONS

Heister RR: Scaphoid Fractures. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (second edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams and Wilkins, 2003, pp 996-997.

Heister RR: Bone Spurs. In: Greenberg’s Atlas of Emergency Medicine. Greenberg M, Hendrickson RG, Silverberg M, Campbell CJ, Morocco A, Salvaggio C, Spencer MT (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005.

Heister RR: Sesamoid Bones. In: Greenberg’s Atlas of Emergency Medicine. Greenberg M, Hendrickson RG, Silverberg M, Campbell CJ, Morocco A, Salvaggio C, Spencer MT (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005.

Davis DP, Heister RR, Ochs M, Hoyt D: The impact of hyperventilation on outcome following paramedic rapid sequence intubation. Neurocritical Care, accepted for publication.

Heister RR, Vadeboncouer TF, Guss DA: Impact of helical computed tomography on negative laparotomy rates in acute appendicitis. Am J Emerg Med. 2006 Jan;24 (1):43-7.

Heister RR, Rao D, Ly BT, Davis DP, Clark RF: Stingray envenomation: A retrospective review of clinical presentation and treatment of 119 cases. The Journal of Emergency Medicine 2007 July 33 (1) 33-37.

Shomorony I, Cirulli ET, Huang L, Napier, LA, Heister, RR … Unsupervised integration of multimodal dataset identifies novel signatures of health and disease. Genome Medicine. 2020 Jan 10; 12.1:7.

Hou YCC, Yu HC, Martin R, Schenker-Ahmed…Heister, RR… Precision Medicine Advancements Using Whole Genome Sequencing, Noninvasive Whole Body Imaging, and Functional Diagnostics. PNAS February 11, 2020 117(6)3053-3062.


Robert Eric Dinenberg, M.D., M.P.H.

As a Health Nucleus physician, engaging in therapeutic relationships brings me meaning and offers an opportunity to bring my passion for coaching mindfulness and other skills for peak performance to each client.

EDUCATION

Occupational Medicine Residency: UCSF Occupational and Environmental Medicine San Francisco, CA (2010.2012)

Masters of Public Health: University of California at Berkeley School of Public Health Berkeley, CA (2010.2011)

Internship, Family Practice Hennepin County Medical Center Minneapolis, MN (2000.2001)

M.D. degree: Medical College of Pennsylvania and Hahnemann University Philadelphia, PA (1994.1999)

BA with Honors in Anthropology University of California Los Angeles Los Angeles, CA (1989-1994)

ACCREDITATIONS

2002 Medical License, State of California
2002 DEA Certification
2000 Founding Diplomat, American Board of Holistic Medicine

PUBLICATIONS

Peer Reviewed Journals:

Dinenberg RE, McCaslin S, Bates M, Cohen E. Social support may protect against development of post-traumatic stress disorder: Findings from the heart and soul study. Am J Health Promot. 2014;28(5):294-7.

Book Chapters:

R E Dinenberg. Health Impact of Lifestyle and Health Promotion, In: Health Promotion in the Workplace, 4th ed. Michael O’Donnell (Ed.), Cengage Learning, Stamford, CT.

R E Dinenberg, M Zappaterra, G Pransky, J Rinker. Disability Management and Prevention. In: Current Occupational & Environmental Medicine, 5th ed., Joseph Ladou (Ed.), McGraw-Hill, NY, New York.

Industry Journals:

R E Dinenberg. Health Protection/Promotion for the Workforce: The Business Case.

Occupational Health & Safety. November 1, 2013.

http://ohsonline.com/articles/2013/11/01/health-protection-promotion-for-theworkforce.aspx

B Schmidt, R E Dinenberg. Total Worker Health Approach Helps Organizations and Employees Thrive. July 1, 2014.

http://ohsonline.com/Articles/2014/07/01/Total-Worker-Health-Approach-Helps-Organizationsand-Employees-Thrive.aspx?Page=1

R E Dinenberg. The National Diabetes Prevention Program: An Evidence-Based Program for Employers, Providers, Health Plans, and Community Groups to Bend the Trend. Managed Care Outlook. 2014;27(1)

R.E. Dinenberg. Models for Diabetes Prevention Go Beyond Traditional Approach. Managed Healthcare Executive. March 7, 2014.

Books:

Dinenberg, Mindfulness and Peak Performance: Touch the Ground, Touch the Sky; National University Press (2005).

Media:

Dinenberg, “Guided Meditations with Dr. Robert Eric Dinenberg”; iTunes Album (2010)


Keegan Duchicela, MD Physician at Health Nucleus

Keegan Duchicela, MD

As a physician specializing in preventative medicine, I am passionate about using technology to inform, empower and guide patients in their journey toward better health.

EDUCATION

Stanford University, Master of Arts, Human Biology (1999-2003)

Stanford University, Master of Arts, Sociology (2002-2003)

MD, University of California, San Francisco - School of Medicine Doctor of Medicine (2003-2007)

San Jose-O'Connor Family Medicine Residency Program (2007-2010)

ACCREDITATIONS

Board Certified, American Board of Family Physicians (2010-Present)
Board of Directors, Cachamsi Medical Spanish program

PRESENTATIONS

44th Annual STFM Spring Conference, Presenter, Wake Up! Introduce an Easy-to-Use and Affordable Audience Response System to Electrify Your Lectures; April 29th, 2011

Healthcare Information and Management Systems Society (HIMSS) National Conference, Invited panelist/ presenter, Using HealthIT to Engage Patients in Underserved Communities, March 5th 2013


Jie Liu, MD, MPH, As a physician at Health Nucleus

Jie Liu, MD, MPH

As a physician at Health Nucleus, I am passionate about using integrative medicine as well as my knowledge as a chronic disease researcher to help my patients preempt disease and create wellness.

EDUCATION

MD: University of California-San Diego 2015

Family Medicine Residency: Family Heathy Centers of San Diego 2018

MPH: Rollins School of Public Health, Emory University 2006

BA: University of Michigan, Ann Arbor, 2004

Adjunct Assistant Professor of Public Health: San Diego State University 2019-present

Core Scientist: Laura Rodriguez Research Institute, FHCSD, San Diego, CA 2019-present

ACCREDITATIONS

State of California Medical License

American Board of Family Medicine

PUBLICATIONS

Liu J, Godino JG, Norman GJ, Hill L, Calfas K, Sallis JF, Arredondo E, Rock CL, Criqui M, Zhu SH, Griffiths K, Covin J, Dillon L, Patrick K. Planned care for obesity and cardiovascular risk reduction using a stepped-down approach: A randomized-controlled trial. Prev Med. 2018 Sep;114:223-231. doi: 10.1016/j.ypmed.2018.07.015. Epub 2018 Jul 25. PubMed PMID: 30055199; PubMed Central PMCID: PMC6130909.

Cai WD, Zhao J, Zhao JK, Raymond HF, Feng YJ, Liu J, McFarland W, Gan YX, Yang ZR, Zhang Y, Tan JG, Wang XR, He ML, Cheng JQ, Chen L. HIV prevalence and related risk factors among male sex workers in Shenzhen, China: results from a time-location sampling survey. Sex Transm Infect. 2010 Feb;86(1):15-20. doi: 10.1136/sti.2009.037440. Epub 2009 Oct 22. PubMed PMID: 19854703.

Feng L, Ding X, Lu R, Liu J, Sy A, Ouyang L, Pan C, Yi H, Liu H, Xu J, Zhao J. High HIV prevalence detected in 2006 and 2007 among men who have sex with men in China's largest municipality: an alarming epidemic in Chongqing, China. J Acquir Immune Defic Syndr. 2009 Sep 1;52(1):79-85. doi: 10.1097/QAI.0b013e3181a4f53e. PubMed PMID: 19448559.


Evelyne Bischof, MD, MPH, Associate professor

As an internal medicine specialist with focus on oncology and longevity, I’m passionate to bring precision medicine by AI- and machine learning data translation towards individualized prevention and treatment. 

EDUCATION

Intern MD Massachusetts General Hospital, Beth Israel Medical Deaconess and Dana Farber (2009-2010), Columbia University (2010-2011)

MD (residency, fellowship, attending physician since 2016) University Hospital Basel, Switzerland

Associate professor Shanghai University of Medicine and Health Sciences, Shanghai (2016-now)

Lecturer, Jiaotong University School of Medicine, Shanghai (2016-now)

Associate professor Shanghai University of Medicine and Health Sciences, Shanghai (2016-now)

President of Swiss Young Internists, 2013-2020

ACCREDITATIONS

Internal medicine board certification (Switzerland)

PUBLICATIONS

Deriving Competencies for Mentors of Clinical and Translational Scholars
“We examined focus groups, the literature, competencies derived for clinical and translational scholars, mentor training curricula, mentor evaluation forms and finally conducted an expert panel process in order to compose this list.”

Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction “This study aimed to validate the diagnostic performance of the 0/1-h algorithm in a large multicenter study.”

Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma “Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer mortality worldwide…”

Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit “The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country….”

Prognostic value of plasma levels of HIF-1a and PGC-1a in breast cancer “Therefore, in our study, we aimed to investigate the role of HIF-1α, as well as PGC-1α in breast cancer tumorigenesis, growth and metastasis…”

Anthracycline induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review) “Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients.”

Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells “BRCA1 and BRCA2 genes are crucial for double-strand break repair by homologous recombination, and mutations in these genes are responsible for most familial breast carcinomas.”

Stromal fibroblast activation and their potential association with uterine fibroids (Review) Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA

To which countries do European psychiatric trainees want to move to and why? “A high number of psychiatric trainees considered moving to another country, and their motivation largely reflects the substantial salary differences. These findings suggest tackling financial conditions and academic opportunities.”

Clinical trials for COVID-19 should include sex as a variable “The number of COVID-19 cases appears to be comparable between men and women, but the severity of disease and death is two times greater for men than for women.”

Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data “BM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors…”

Pyrosequencing quantified methylation level of BRCA1 promoter as prognostic factor for survival in breast cancer patient “Breast cancer is the most common noncutaneous cancer and the leading cause of cancer deaths among women…”


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